1989.03. - 1993.02. Korea University, Bachelor (Majored in Biology)


1993.09. - 1995.08. Korea University, Master (Majored in Cell Biology)


1995.09. - 1999.02. Korea University, Ph.D. (Majored in Cell Biology)

2000.03. - 2002.02. Korea National Institute of Health, Postdoc Associate


2002.03. - 2006.02. Seoul National Univiersity, National Creative Research Initiatives
for ARS network, Principal Investigator


2006.03. - 2010.02 Pusan National University, Dept. Molecular Biology,
Assistant Professor

2010. 03- present Pusan National University, Dept. Molecular Biology, Associate Prof.

2013. 08. - 2014. 08 Visiting Scientst. MD Anderson Cancer Center.


2010.03. - present Pusan National University, Dept. of Molecular Biology,
Associate Professor

2008.02 KSMCB Winter Conference 2008 Blue Ribbon Lecture

2009 - 2010 The members of the KSMCB Molecular Biology News Committee

2009 - 2010 The members of the KSMCB Academic Research Awards Committee

2009 - 2013 The members of the KSMCB Education Committee

2011 The Korean version of the biology of cancer ( Robert A. Weinberg)

Lee SH, Woo TG, Lee SJ, Kim JS, Ha NC, Park BJ. Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system. Oncotarget. 2013 Dec;4(12):2523-31.

Azmi AS, Bollig-Fischer A, Bao B, Park BJ, Lee SH, Yong-Song G, Dyson G, Reddy CK, Sarkar FH, Mohammad RM. Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25. BMC Syst Biol. 2013 Sep 3;7:85.

Lee HS, Kim DG, Oh YS, Kwon NH, Lee JY, Kim D, Park SH, Song JH, Lee S, Han JM, Park BJ, Lee J, Kim S. Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression. Biochem J. 2013 Sep 15;454(3):411-6.

Jung YS, Lee SJ, Lee SH, Chung JY, Jung YJ, Hwang SH, Ha NC, Park BJ. Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity. Cell Cycle. 2013 Jul 15;12(14):2277-90.

Lee SJ, Lee SH, Yoon MH, Park BJ. A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation. Neoplasia. 2013 Jul;15(7):727-37.

Jung YS, Lee SJ, Lee SH, Chung JY, Jung YJ, Hwang SH, Ha NC, Park BJ. Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity. Cell Cycle. 2013 Jun 20;12(14).

Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol WG, Lee J, Park BJ. Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity. Lab Invest. 2013 Jun;93(6):663-76.

Lee H, Woo YJ, Kim SS, Kim SH, Park BJ, Choi D, Jang KL. Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-β2 expression via DNA methylation. Cancer Lett. 2013 Jul 28;335(2):372-9.

Jung YS, Lee SJ, Yoon MH, Ha NC, Park BJ. Estrogen receptor α is a novel target of the Von Hippel-Lindau protein and is responsible for the proliferation of VHL-deficient cells under hypoxic conditions. Cell Cycle. 2012 Dec 1;11(23):4462-73.

Lee SH, Jung YS, Chung JY, Oh AY, Lee SJ, Choi DH, Jang SM, Jang KS, Paik SS, Ha NC, Park BJ. Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway. Cell Death Dis. 2011 Dec 1;2:e235.

Choi JW, Kim DG, Lee AE, Kim HR, Lee JY, Kwon NH, Shin YK, Hwang SK, Chang SH, Cho MH, Choi YL, Kim J, Oh SH, Kim B, Kim SY, Jeon HS, Park JY, Kang HP, Park BJ, Han JM, Kim S. Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis. PLoS Genet. 2011 Mar;7(3):e1001351.

Chung JY, Lee SJ, Lee SH, Jung YS, Ha NC, Seol W, Park BJ. Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease. Neurosignals. 2011;19(2):86-96.

Lee SH, Park BJ. p53 activation by blocking Snail: a novel pharmacological strategy for cancer. Curr Pharm Des. 2011;17(6):610-7. Review.

Piao S, Lee SJ, Xu Y, Gwak J, Oh S, Park BJ, Ha NC. (공동교신). CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation. Cell Cycle. 2011 Feb 1;10(3):531-7.

Oh YS, Kim DG, Kim G, Choi EC, Kennedy BK, Suh Y, Park BJ, Kim S. Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging Cell. 2010 Oct;9(5):810-22.

Lee SH, Shen GN, Jung YS, Lee SJ, Chung JY, Kim HS, Xu Y, Choi Y, Lee JW, Ha NC, Song GY, Park BJ. Antitumor effect of novel small chemical inhibitors of Snail-p53 binding in K-Ras-mutated cancer cells. Oncogene. 2010 Aug 12;29(32):4576-87.

Yang DJ, Chung JY, Lee SJ, Park SY, Pyo JH, Ha NC, Yoo MA, Park BJ. Slug, mammalian homologue gene of Drosophila escargot, promotes neuronal-differentiation through suppression of HEB/daughterless. Cell Cycle. 2010 Jul 15;9(14):2789-802.

Kim CH, Jeon HM, Lee SY, Jeong EK, Ju MK, Park BJ, Park HG, Lim SC, Han SI, Kang HS. Role of reactive oxygen species-dependent protein aggregation in metabolic stress-induced necrosis. Int J Oncol. 2010 Jul;37(1):97-102.

Lee SJ, Lee SH, Ha NC, Park BJ. Estrogen prevents senescence through induction of WRN, Werner syndrome protein. Horm Res Paediatr. 2010;74(1):33-40.

Xu Y, Lee SH, Kim HS, Kim NH, Piao S, Park SH, Jung YS, Yook JI, Park BJ, Ha NC. Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene. 2010 May 27;29(21):3124-33.

Lee SJ, Jung YS, Lee SH, Chung HY, Park BJ. Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. Int J Oncol. 2009 Jun;34(6):1637-43.

Lee SH, Lee SJ, Chung JY, Jung YS, Choi SY, Hwang SH, Choi D, Ha NC, Park BJ. p53, secreted by K-Ras-Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker. Oncogene. 2009 May 14;28(19):2005-14.

Yum S, Lee SJ, Piao S, Xu Y, Jung J, Jung Y, Oh S, Lee J, Park BJ, Ha NC. The role of the Ser/Thr cluster in the phosphorylation of PPPSP motifs in Wnt coreceptors. Biochem Biophys Res Commun. 2009 Apr 10;381(3):345-9.

Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.

Lee SH, Lee SJ, Jung YS, Xu Y, Kang HS, Ha NC, Park BJ. Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia. 2009 Jan;11(1):22-31.

Jang YH, Namkoong S, Kim YM, Lee SJ, Park BJ, Min DS. Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway. Cell Death Differ. 2008 Nov;15(11):1782-93.

Piao S, Lee SH, Kim H, Yum S, Stamos JL, Xu Y, Lee SJ, Lee J, Oh S, Han JK, Park BJ, Weis WI, Ha NC. Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One. 2008;3(12):e4046.

Han JM, Park BJ, Park SG, Oh YS, Choi SJ, Lee SW, Hwang SK, Chang SH, Cho MH, Kim S. AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11206-11.

Kan H, Kim CH, Kwon HM, Park JW, Roh KB, Lee H, Park BJ, Zhang R, Zhang J, Soderhall K, Ha NC, Lee BL. Molecular control of phenoloxidase-induced melanin synthesis in an insect. J Biol Chem. 2008 Sep 12;283(37):25316-23.

Han JM, Park SG, Liu B, Park BJ, Kim JY, Jin CH, Song YW, Li Z, Kim S. Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. Am J Pathol. 2007 Jun;170(6):2042-54.

Lee SH, Lee SJ, Kim JH, Park BJ. Chemical carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine, is a specific activator of oncogenic Ras. Cell Cycle. 2007 May 15;6(10):1257-64.

Park BJ, Oh YS, Park SY, Choi SJ, Rudolph C, Schlegelberger B, Kim S. AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability. Cancer Res. 2006 Jul 15;66(14):6913-8.

Park SG, Kim HJ, Min YH, Choi EC, Shin YK, Park BJ, Lee SW, Kim S. Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. Proc Natl Acad Sci U S A. 2005 May 3;102(18):6356-61.

Park SG, Shin H, Shin YK, Lee Y, Choi EC, Park BJ, Kim S.The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am J Pathol. 2005 Feb;166(2):387-98.

Park BJ, Kang JW, Lee SW, Choi SJ, Shin YK, Ahn YH, Choi YH, Choi D, Lee KS, Kim S. The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. Cell. 2005 Jan 28;120(2):209-21.

Kim YY, Park BJ, Kim DJ, Kim WH, Kim S, Oh KS, Lim JY, Kim J, Park C, Park SI. Modification of serine 392 is a critical event in the regulation of p53 nuclear export and stability. FEBS Lett. 2004 Aug 13;572(1-3):92-8.

Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG. Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. Oncogene. 2003 Jul 10;22(28):4314-32.

Kim MJ, Park BJ, Kang YS, Kim HJ, Park JH, Kang JW, Lee SW, Han JM, Lee HW, Kim S. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Nat Genet. 2003 Jul;34(3):330-6.

Kim YY, Park BJ, Seo GJ, Lim JY, Lee SM, Kimm KC, Park C, Kim J, Park SI. Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation. Biochem Biophys Res Commun. 2003 Dec 12;312(2):426-33.

Park SJ, Kim YY, Ju JW, Han BG, Park SI, Park BJ. Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation. Biochem Biophys Res Commun. 2001 Dec 21;289(5):1205-10.

Park SJ, Kim YY, Lim JY, Seo GJ, Kim J, Park SI, Park BJ. Opposite role of Ras in tumor necrosis factor-alpha-induced cell cycle regulation: competition for Raf kinase. Biochem Biophys Res Commun. 2001 Oct 12;287(5):1140-7.

Park BJ, Park JI, Byun DS, Park JH, Chi SG. Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer. Cancer Res. 2000 Jun 1;60(11):3031-8.

Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG. Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma. Clin Cancer Res. 2000 May;6(5):1767-72.

Park BJ, Lee SJ, Kim JI, Lee SJ, Lee CH, Chang SG, Park JH, Chi SG. Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res. 2000 Jul 1;60(13):3370-4.